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KMID : 0360219690100030019
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Journal of the Korean Ophthalmological Society
1969 Volume.10 No. 3 p.19 ~ p.23
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The effects of anti-inflammatory agents on blood-aqueous-barrier in experimental uveitis
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Abstract
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The purpose of this paper is to study the effects of anti-inflammatory agents on the blood-aqueousbarrier in experimentally induced uveitis. 10% solution of sodium fluorescein was injected intrvenously in the ear vein of rabbits (0.25 ml/kg) and fluorescein curve was drawn after the method of Amsler and Huber.
Experimental uveitis was induced by the injection of 0. 2 ml of human serum into the vitreous body.
After uveitis had been induced, three kinds of anti-inflammatory agents-Prednisolone, Benzyron and Methotrexate were given orally.
In control animals in which no uveitis was induced, no changes in fluorescein curve were demonstrated .before and after the administrations of drugs.
In animals with uveitis, marked increases of the blood-aqueous barrier were noted. When Benoyron and Prednisolone were given to these animals, normalization of the fluorescein curves were demonstrated.
Methotrexate had no effects on--the-fluorescein curves in uveitis animals, showing no improvements in the permeability of uveal vessels. This ineffectiveness seemed to be due to the resistance of rabbits to methotrexate.
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